May 1, 2006


Nora Volkow, M.D.

Director

National Institute on Drug Abuse

6001 Executive Boulevard, Room 5213

Bethesda, MD  20892-9561


Re:  Use of nonhuman animals in drug-addiction research


Dear Dr. Volkow:


I am writing you in order to express my profoundly felt objection to the use of nonhuman animals in drug-addiction research studies.  While I understand that animal models can help us to understand the biological effects of drug abuse, they cannot hope to address the many complex socioeconomic factors that lead to, and allow for the continuation of, such abuse in humans.  Moreover, I along with many others have come to believe that there is a moral imperative which holds that the use of nonhuman animals for research purposes not only violates those individual animals' right to live free of exploitation, but also degrades human beings as well.  The anthropocentric belief that we humans are intrinsically superior to nonhuman animals, and are thus justified in using those animals to increase our own sense of safety and well-being, is a position which undermines our relationship with the world of nature:  it creates an us and them scenario which not only results in suffering for those animals selected for use in research studies, but also constitutes a violation of the integrity of our relationship to the natural world from which we ourselves sprang, and with which our lives remain inextricably intertwined.  There is, in reality, no us and them; rather, we are all part of a greater whole – and the damage we inflict upon nature and its other inhabitants is, ultimately, a damage we inflict upon ourselves.


Although I am not a scientist and cannot pretend to understand the intricacies of the biological aftereffects that drug addiction causes (and which are now being studied via animal models), the "gains" in understanding touted by those who have performed animal studies in the past are, to speak frankly, difficult to take seriously.  I have, for instance, read that:  "The discovery that animals will readily self-administer addictive drugs when given the opportunity has reshaped the health community's view of drug abusers. It is now widely understood that addiction – both physical and psychological – is a neuro-behavioral problem to which all people are susceptible."  In other words, many or perhaps all human beings have an inherent proclivity towards getting high.  How can I put my response to this discovery politely?  "Duh," I'm afraid, will have to do.  Again, I have read:  "Animal research demonstrating the power of behaviorally conditioned responses to the environment has helped explain why relapse into drug abuse is common. Even after the physical dependency has been eliminated, an animal or person placed again in the environment associated with drug abuse will reacquire the desire for drugs."  In other words, if you continue to hang out with people who like to get high (and/or do not deal with those stressors that make you want to use drugs for escapist purposes in the first place), you will likely fall back into your previous pattern of addictive behavior.  Again, duh.  I apologize for my rudeness here, but these sorts of "discoveries" represent insights any sociological study into the problem would readily reveal.


Other research involves exposing animals ranging from mice to baboons to drugs commonly abused by humans in order to discover how they may damage the brain.  This form of research is one I most particularly object to, for in this day and age virtually everyone understands that methamphetamines, cocaine, "ecstasy" (MDMA), etc. will endanger their health; certainly everyone is aware which drugs our society has deemed legal to use and which not.  That we should continue to subject nonhuman animals to research procedures which involve repeatedly, and often forcibly, exposing them to addictive chemicals in order that we may later examine their brains to observe how much damage has occurred is to condone the purposeful infliction of suffering and death on other sentient beings so that we can better understand how those humans who indulge in behaviors already recognized to be both dangerous and illegal will be affected.  Not only is this morally reprehensible (it treats nonhuman animals as a means to an end rather than acknowledging them as having desires and interests of their own which are deserving of respect), it also, once again, undermines the importance those animals have as constituent members of that larger whole of which we humans are but a part.  By undermining that fundamental understanding, an understanding which is of primary importance if we are to successfully repair the damage we have already done to the natural world, drug-addiction researchers become part of the problem, not part of the solution.  The dysfunction which currently characterizes the relationship humans have with our natural environment endangers us all; that dysfunction is exemplified by the use of nonhuman animals as research "tools," and such use must, therefore, cease.  The problems we humans have with regard to dealing with the stressors inherent to our modern, "civilized" way of life are of our own making; how we deal with those stressors is our own responsibility.  To shirk this responsibility and place it on the shoulders of nonhuman animals is ethically irresponsible, both to them and to ourselves.


Other areas of investigation into the realm of drug-addiction exist, and offer greater insights into the problem without the dangers touched upon above.  These include the use of ethical human clinical trials, genetic studies, treatment assessments, behavior modification trials, and pathology studies.  Please stop funding the abusive treatment of innocent animals in drug-related studies and fund these more effective alternatives exclusively.



Yours sincerely & etc. . . .







Four Sample Drug Studies Involving Nonhuman Primates:


Self-Administration of Cocaine-Heroin Combinations by Rhesus Monkeys (1998)


Location Preference Related to Smoked Heroin Self-Administration by Rhesus Monkeys (2001)


Effect of Cocaine on Cell Proliferation in the Cerebral Wall of Monkey Fetuses (2001)


Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA (2002)


Retraction of MDMA Paper (2003)






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